Antifungal Susceptibility Pattern of Candida Albicans in Human Infections
Kamal Uddin Zaidi, Abin Mani*, Richa Parmar, Vijay Thawani
Identifiers and Pagination:Year: 2018
First Page: 1
Last Page: 6
Publisher Id: BIOLSCI-4-1
Article History:Received Date: 22/11/2017
Revision Received Date: 26/01/2018
Acceptance Date: 27/01/2018
Electronic publication date: 28/02/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Candida albicans is an opportunistic pathogen under immune-compromised conditions and despite anti-fungal therapies, it has become lethal. Increase in the antimicrobial resistance in C. albicans is a matter of concern since it is in the human microbiome.
Aims and Objectives:
This study was conducted to estimate the incidence of C. albicans in infections, and evaluate its antifungal susceptibility in clinical samples.
Methods and Materials:
Two hundred isolates of C. albicans from different clinical samples were analyzed against its susceptibility towards four antifungal agents (fluconazole, ketoconazole, itraconazole and amphotericin-B) using well diffusion and MIC by microdilution assay.
All isolates in the study were sensitive to amphotericin-B and ketoconazole and a high frequency of fluconazole and itraconazole resistance was observed. Oral and catheter tips were observed to be the major sites of C. albicans infections. Significant resistance aganist fluconazole (56.5%) and itraconazole (64.5%) was observed with MIC at 16, 32 to 64μg/ml. All isolates were observed to be sensitive for ketoconazole and amphotericin-B at 0.5μg/ml and 1μg/ml.
The study shows a higher antibiotic resistance in the clinical samples which proves the risk in C. albicans management program.