The Role of Disease in Organic Progress

David Sephiashvili*
Tbilisi State Medical University, Oncologic Dispensary, Post Code 0112, Georgia

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©David Sephiashvili; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Tbilisi State Medical University, Oncologic Dispensary, Post Code 0112, Georgia; Tel: +9950322346287; E-mail:


On the basis of some paleontological readings, the main macro evolutionary changes take place only in the period of ecological crisis. Since the organic progress is a complication of the internalorganization of live systems, it may lead to a logical inference that the indispensable condition complexity of the internal organization is an alteration of homeostasis. But, a stable disturbance of homeostasis is called “disease”. Consequently, disease is prerequisite for the organic progress.

Disease is a breakage of self-controlling and regulation, including genetic processes. How reads, interprets a damaged cell the hereditary information? In the case of a non-classical transfer of genetic information, the above-stated question deserves a specific treatment. There is reason to assume, that the “erroneously” or “alternatively” realized genetic information in the damaged cells may become one of the major factor-provider of the evolutionary material.

The micro-changes of the genetic activity in the damaged cells are not ignored by the “magnifying lens of natural selection”. Better adapted organisms survive and multiply successfully.

The complication of the inner structure- an organic progress is an answerable reaction for the influence of pathological factors, which takes place on the historical periods (for example while global ecological catastrophes). The aim of it is a restoration of damaged homeostasis – recovering of flum, by creating the new evolution forms. Typical pathologic processes are the tools for the creation of new forms during the process of organic development (progress).

The excess of pathologic substrate detected at the onset of an individual development, both at the tissue, cellular and molecular levels, confirms that disease played an important role in the evolutionary transformations. Complex genetic, metabolic, morphologic changes that take place in embryogenesis are the reflection, in a tiny model, of those pathologic processes, to which adult ancestor embryos had been exposed on the corresponding stages of phylogenetic development, while ontogenesis itself presents a short history of disease of filum. By those characteristic nuances of the pathologic changes which take place in the developing organs, we may surmise, which pathology might have been the cause of those changes in the process of the organic progress. Disease itself is a developing style of living matter. Pathology, as a process of struggle for survival, is the only way, an essential condition of the progressive evolution. The progressive evolutionary objects were diseased organisms, “hopeful patients”. Pathology is a lack circle of evolution theory, some kind of Terra incognita, where there is hidden the answers of many actual questions of Evolution theory.

Keywords: Adaptation, disease, environmental conditions, homeostasis, organic progress, pathological process.